Translation & Proteostasis
Gene co-expression module in Gamma-delta T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 24 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 24 genes have a known function matching the annotation |
Why this annotation
The top hub genes EIF4B and EIF2S3 are translation initiation factors; EEF2 is a translation elongation factor; TPT1 (TCTP) is a translation regulator; HYOU1 is an ER stress-induced chaperone (GRP170 family). LSM14A is involved in mRNA processing/stress granules. UBR5, USP34, and RNF40 belong to the ubiquitin system linked to proteostasis. The module is moderately coherent, suggesting a mixed but related translation/proteostasis program. CRKL and RASSF5 are somewhat peripheral. The moderate coherence and several weak-membership genes indicate a mixed program combining translation and protein quality control.
Genes
ARAP2, ATG13, BRPF1, CLINT1, CRKL, E2F3, EEF2, EIF2AK2, EIF2S3, EIF4B, GOLGA4, HERC2, HYOU1, JADE2, LSM14A, PLCG1, RASSF5, RNF40, RSL1D1, SFI1, TPT1, UBR5, USP34, USP4
Most correlated modules
- mRNA Splicing Processing · correlation 0.83
- Hippo Pathway Signaling · correlation 0.82
- Vesicular Trafficking · correlation 0.82
- T cell Identity Signaling · correlation 0.81
- ER Antigen Processing · correlation 0.81
- Nuclear Pore Organization · correlation 0.81
- ER Protein Translocation · correlation 0.80
- Chromatin Epigenetic Regulation · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.