ARAP2 — ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARAP2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARAP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Integrin Adhesion Migration migration & adhesion | ATF7IP, C4orf3, CLEC2B, COTL1, CTSH, DEK, DIAPH1, EML4 +11 more | View in SCUBA |
| Gamma-delta T cells | Translation & Proteostasis RNA processing & translation | ATG13, BRPF1, CLINT1, CRKL, E2F3, EEF2, EIF2AK2, EIF2S3 +15 more | |
| Mucosal-associated invariant T cell | Cytoskeletal Organization Cytoskeletal | CHD8, CTNNB1, DYNC1H1, EP400, NFATC2, RASSF2, RNF4, SRPRA +4 more |
About the gene
| Synonyms | CENTD1, PARX |
|---|---|
| Chromosome | 4: 35948221-36244514 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | GTPase activation |
Function
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase- activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.