E2F3 — E2F transcription factor 3
E2F3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
E2F3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | MAPK feedback signaling TCR/AP1/NFKb pathway | BACH1, DUSP16, DUSP4, EPSTI1, MAT2B, PELI1, PIM2, SEC14L1 +2 more | View in SCUBA |
| Enterocytes | Epithelial NF-kB response Inflammation | ATP10B, CASP1, CCL28, FAM135A, GSKIP, INPP4B, LYN, MRTFA +4 more | View in SCUBA |
| Gamma-delta T cells | Translation & Proteostasis RNA processing & translation | ARAP2, ATG13, BRPF1, CLINT1, CRKL, EEF2, EIF2AK2, EIF2S3 +15 more |
About the gene
| Chromosome | 6: 20401879-20493714 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Cell cycle, Transcription, Transcription regulation |
Function
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.