ATP10B — ATPase phospholipid transporting 10B (putative)
ATP10B belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATP10B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Epithelial NF-kB response Inflammation | CASP1, CCL28, E2F3, FAM135A, GSKIP, INPP4B, LYN, MRTFA +4 more | View in SCUBA |
About the gene
| Synonyms | ATPVB, FLJ21477, KIAA0715 |
|---|---|
| Chromosome | 5: 160563120-160852214 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Translocase |
| Biological process | Lipid transport, Transport |
Function
Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of lysosome membranes. Plays an important role in the maintenance of lysosome membrane integrity and function in cortical neurons
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.