Epithelial NF-kB response
Gene co-expression module in Enterocytes
| Category | Inflammation |
|---|---|
| Genes | 13 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 13 genes have a known function matching the annotation |
Why this annotation
Epithelial innate immune activation is suggested by NFKBIZ (NF-kB/IL-17 target), CASP1 (inflammasome), CCL28 (mucosal chemokine), LYN and VMP1. ATP10B, SLC37A1 and RRBP1 are secretory/ER genes. Together these indicate an inflammatory epithelial response, consistent with neighbor M39.
Genes
ATP10B, CASP1, CCL28, E2F3, FAM135A, GSKIP, INPP4B, LYN, MRTFA, NFKBIZ, RRBP1, SLC37A1, VMP1
Most correlated modules
- Inflammatory cell death · correlation 0.87
- Epithelial junction adhesion · correlation 0.80
- IFN-gamma STAT1 signaling · correlation 0.80
- Focal adhesion actin · correlation 0.78
- DUOX2 oxidative defense · correlation 0.78
- STAT3/JNK signaling · correlation 0.76
- IFN-gamma immunoproteasome · correlation 0.74
- Long-gene intronic signal · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.