ATP6V1C1 — ATPase H+ transporting V1 subunit C1
ATP6V1C1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATP6V1C1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Endolysosomal Trafficking Lysosomal & pahgocytosis | ACVR1, ATAD1, CSNK2A1, CTNNB1, DDX6, EMILIN2, GNAI3, GTF2H1 +17 more | View in SCUBA |
About the gene
| Synonyms | ATP6C, ATP6D, VATC, Vma5 |
|---|---|
| Chromosome | 8: 103021063-103073051 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins, Transporters |
| Biological process | Hydrogen ion transport, Ion transport, Transport |
Function
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.