GNAI3 — G protein subunit alpha i3
GNAI3 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GNAI3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Ubiquitin Protein Homeostasis Housekeeping | ARPC2, BZW1, CMTM6, CSNK1A1, DAP, EMP2, KIF5B, MORF4L1 +6 more | View in SCUBA |
| Innate lymphoid cells | mRNA Stability & Splicing RNA processing & translation | BUD31, EIF4G2, HSPA9, PABPC1, PABPC4, PAIP2, PAPOLA, PRKAR1A +6 more | View in SCUBA |
| Macrophages | Endolysosomal Trafficking Lysosomal & pahgocytosis | ACVR1, ATAD1, ATP6V1C1, CSNK2A1, CTNNB1, DDX6, EMILIN2, GTF2H1 +17 more | View in SCUBA |
| Mucosal-associated invariant T cell | Metabolic Homeostasis Housekeeping | ADIPOR1, BIRC3, COQ10B, CREBRF, EIF1AX, H2AC20, KLF11, KLHL18 +10 more | |
| Pericytes | Proteostasis Quality Control Housekeeping | DNAJB6, HNRNPF, HSP90AB1, HSPE1, MAP1LC3B, MRPL18, UBE2D3 | View in SCUBA |
About the gene
| Synonyms | 87U6 |
|---|---|
| Chromosome | 1: 109548615-109600195 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Transducer |
| Biological process | Cell cycle, Cell division |
Function
Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels. Stimulates the activity of receptor-regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division. The active GTP-bound form activates the calcium permeant TRPC5 ion channels.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.