ATAD1 — ATPase family AAA domain containing 1
ATAD1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATAD1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Immune Negative Regulation Immune regulation | CABIN1, DGLUCY, FYB1, GMIP, ICE2, KMT5B, NFX1, NLRC3 +4 more | |
| Macrophages | Endolysosomal Trafficking Lysosomal & pahgocytosis | ACVR1, ATP6V1C1, CSNK2A1, CTNNB1, DDX6, EMILIN2, GNAI3, GTF2H1 +17 more | View in SCUBA |
About the gene
| Synonyms | FLJ14600, Msp1 |
|---|---|
| Chromosome | 10: 87751512-87841361 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted membrane proteins |
| Molecular function | Translocase |
Function
Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria. Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP- dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (By similarity). Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.