Endolysosomal Trafficking
Gene co-expression module in Macrophages
| Category | Lysosomal & pahgocytosis |
|---|---|
| Genes | 26 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 26 genes have a known function matching the annotation |
Why this annotation
Hub genes ATP6V1C1 (V-ATPase, lysosomal acidification), VPS26A/VPS37A (retromer endosomal sorting), RAB5A (early endosome), SLC17A5 (lysosomal sialin), IGF2R (mannose-6-phosphate/lysosomal targeting receptor), SOAT1 (cholesterol esterification in ER/lysosomes), TMEM165 (Golgi/lysosomal ion transport) collectively define an endolysosomal vesicle sorting and trafficking program. VAPA (ER-endosome membrane contact), CTNNB1 and GNAI3 add signaling context. Mono_mac enrichment is consistent with active phagocytic/lysosomal activity in monocyte-derived macrophages.
Genes
ACVR1, ATAD1, ATP6V1C1, CSNK2A1, CTNNB1, DDX6, EMILIN2, GNAI3, GTF2H1, IGF2R, MAPKAPK5, MFSD11, PGGT1B, POLR2B, RAB22A, RAB5A, SLC17A5, SOAT1, TFG, TMEM165, TMEM41B, UBQLN1, VAPA, VPS26A, VPS37A, ZNF562
Most correlated modules
- Endolysosomal Trafficking · correlation 0.97
- RAB-mediated Trafficking · correlation 0.96
- Microtubule Organization · correlation 0.96
- RAS-MAPK Signaling · correlation 0.95
- RNA Processing Regulation · correlation 0.95
- ER Membrane Homeostasis · correlation 0.95
- Ubiquitin-ERAD Proteostasis · correlation 0.95
- ER-Golgi Trafficking · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.