GTF2H1 — General transcription factor IIH subunit 1
GTF2H1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GTF2H1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Endolysosomal Trafficking Lysosomal & pahgocytosis | ACVR1, ATAD1, ATP6V1C1, CSNK2A1, CTNNB1, DDX6, EMILIN2, GNAI3 +17 more | View in SCUBA |
About the gene
| Synonyms | BTF2, P62, TFIIH |
|---|---|
| Chromosome | 11: 18322295-18367045 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Essential proteins, Predicted intracellular proteins |
| Biological process | DNA damage, DNA repair, Host-virus interaction, Transcription, Transcription regulation |
Function
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.