BLOC1S2 — Biogenesis of lysosomal organelles complex 1 subunit 2
BLOC1S2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BLOC1S2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Vesicular trafficking Housekeeping | ACSL4, ARL8B, C3orf38, DTX3L, EFCAB14, GGA2, HMGXB3, INPP4A +17 more | View in SCUBA |
| Macrophages | Mitochondrial Housekeeping Mitochondrial & OxPhos | BUD31, C14orf119, CCT5, CDC26, DGUOK, EIF2S1, GADD45GIP1, LSM1 +11 more | View in SCUBA |
About the gene
| Synonyms | BLOS2, BORCS2, FLJ30135, MGC10120 |
|---|---|
| Chromosome | 10: 100273280-100286680 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (By similarity). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May play a role in cell proliferation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.