Mitochondrial Housekeeping
Gene co-expression module in Macrophages
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 20 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
Module contains MRPS10 and MRPL47 (mitochondrial ribosomal proteins), UQCRC1 (Complex III subunit), NDUFB9 (Complex I subunit), MTCH2 (mitochondrial carrier homolog), alongside CCT5 (chaperonin/TRiC complex), PSMD14 (proteasome lid subunit), EIF2S1 (translation initiation), LSM1 (RNA splicing/decay), DGUOK (mitochondrial deoxyguanosine kinase), GADD45GIP1 (mitochondrial matrix protein), CDC26 (APC/C subunit). The mitochondrial ribosomal and OxPhos genes are the most coherent sub-program. All genes show weak membership and uniform expression, suggesting a loosely defined module. Neighbor context (M78, M6 with proteasome genes; M54 with ER genes) places this in a housekeeping network. The mitochondrial component is the strongest identifiable signal.
Genes
BLOC1S2, BUD31, C14orf119, CCT5, CDC26, DGUOK, EIF2S1, GADD45GIP1, LSM1, LYAR, MAGOH, MRPL47, MRPS10, MTCH2, NDUFB9, PCMT1, PSMD14, RNF7, TIPRL, UQCRC1
Most correlated modules
- Proteasome UPS · correlation 0.99
- Proteasome UPS · correlation 0.96
- Mixed Housekeeping · correlation 0.95
- ER Protein Processing · correlation 0.95
- Glycolytic Redox Metabolism · correlation 0.94
- ATP Synthase Complex · correlation 0.94
- Protein Biogenesis · correlation 0.94
- ERAD Proteasome · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.