C1QTNF12 — C1q and TNF related 12
C1QTNF12 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
C1QTNF12's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Mitophagy Stress Response Stress | CDA, CPNE2, FAM219A, FCN3, GSDMC, IGFBP3, INSR, MAP3K6 +7 more | View in SCUBA |
About the gene
| Synonyms | ADIPOLIN, C1QDC2, CTRP12, FAM132A, MGC105127 |
|---|---|
| Chromosome | 1: 1242446-1246722 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Predicted secreted proteins |
| Molecular function | Hormone |
Function
Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.