IGFBP3 — Insulin like growth factor binding protein 3
IGFBP3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IGFBP3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytotoxic effector Cytotoxicity | ADAM23, CTSW, EMP3, FKBP2, IFITM2, KLRG1, LYAR, PLP2 +11 more | View in SCUBA |
| Endothelial | Mitophagy Stress Response Stress | C1QTNF12, CDA, CPNE2, FAM219A, FCN3, GSDMC, INSR, MAP3K6 +7 more | View in SCUBA |
| Fibroblasts | Quiescent Anti-inflammatory Fibroblast Developmental | ADIRF, CHCHD10, DACH1, FXYD6, KHDRBS3, LSP1, NDRG2, PDE1A +3 more | View in SCUBA |
| Smooth muscle cells | Neural Adhesion Program Development | CHL1, CNTN4, DSEL, EMID1, F3, MATN2, SSC5D, STMN2 +1 more | View in SCUBA |
About the gene
| Synonyms | BP-53, IBP3 |
|---|---|
| Chromosome | 7: 45912245-45921874 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Growth factor binding |
| Biological process | Apoptosis |
Function
Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Also exhibits IGF- independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Inhibits the positive effect of humanin on insulin sensitivity. Promotes testicular germ cell apoptosis. Acts via LRP- 1/alpha2M receptor, also known as TGF-beta type V receptor, to mediate cell growth inhibition independent of IGF1. Mechanistically, induces serine-specific dephosphorylation of IRS1 or IRS2 upon ligation to its receptor, leading to the inhibitory cascade. In the nucleus, interacts with transcription factors such as retinoid X receptor-alpha/RXRA to regulate transcriptional signaling and apoptosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.