Mitophagy Stress Response
Gene co-expression module in Endothelial
| Category | Stress |
|---|---|
| Genes | 16 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 16 genes have a known function matching the annotation |
Why this annotation
Hub gene PINK1 is the master regulator of mitophagy, recruiting Parkin to depolarized mitochondria. Supporting genes include INSR (metabolic/insulin signaling), IGFBP3 (IGF axis, metabolic stress), MAP3K6 (stress-activated MAPK), GSDMC (gasdermin family, cell death), and PKN1 (stress-responsive kinase). The module is significantly upregulated in UC inflammation and reverses in remission, consistent with mitochondrial stress in inflamed endothelium. PINK1-driven mitophagy is a known response to inflammatory metabolic stress in vascular cells.
Genes
C1QTNF12, CDA, CPNE2, FAM219A, FCN3, GSDMC, IGFBP3, INSR, MAP3K6, MPZL2, MYO1C, PINK1, PKN1, PLXNA2, SLC44A2, TNS2
Most correlated modules
- Integrin-Actin Adhesion · correlation 0.89
- Endothelial Junction Identity · correlation 0.88
- Endothelial Lipid Signaling · correlation 0.85
- Actomyosin Contractility · correlation 0.83
- Endothelial Angiogenic Identity · correlation 0.83
- Angiogenic Endothelial Identity · correlation 0.82
- Venous Endothelial Identity · correlation 0.81
- Arterial EC Identity · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.