CABLES1 — Cdk5 and Abl enzyme substrate 1
CABLES1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CABLES1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Transcriptional Kinase Regulation Housekeeping | BNC2, CACNB4, CDK8, ENOX2, FAF1, FOXO1, INPP4B, JMY +17 more | View in SCUBA |
About the gene
| Synonyms | FLJ35924, HsT2563 |
|---|---|
| Chromosome | 18: 23134564-23260470 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Cyclin |
| Biological process | Cell cycle, Cell division |
Function
Cyclin-dependent kinase binding protein. Enhances cyclin- dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.