Transcriptional Kinase Regulation
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 26 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 26 genes have a known function matching the annotation |
Why this annotation
CDK8 (Mediator-associated kinase regulating transcription), FOXO1 (forkhead transcription factor integrating metabolic/stress signals), KLF12 (Krüppel-like transcription factor), CABLES1 (CDK5/ABL linker involved in cell cycle checkpoint), and JMY (p53 coactivator/actin nucleator) suggest a transcriptional regulatory program. MYO1D and JMY add cytoskeletal components. PDK3 and MCU link to mitochondrial metabolism. Multiple genes are not detected, indicating low expression. The module is weakly coherent; the most consistent theme is transcriptional kinase-mediated regulation.
Genes
BNC2, CABLES1, CACNB4, CDK8, ENOX2, FAF1, FOXO1, INPP4B, JMY, KLF12, MCU, MYO1D, NCKAP5, PCNX2, PDK3, PELI1, PPFIBP2, SLC22A23, SLC45A4, SRGAP1, TBC1D16, TBC1D22A, TMEM156, UBE2E2, UNC13B, WDR70
Most correlated modules
- Endosomal Rab Trafficking · correlation 0.97
- Transcriptional Regulation · correlation 0.96
- Ubiquitin Proteasome Regulation · correlation 0.96
- Golgi Vesicle Trafficking · correlation 0.96
- MAPK Stress Kinase · correlation 0.94
- ER Stress Response · correlation 0.90
- Macrophage Migration · correlation 0.89
- PI3K Lipid Signaling · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.