ENOX2 — Ecto-NOX disulfide-thiol exchanger 2
ENOX2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ENOX2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Transcriptional Kinase Regulation Housekeeping | BNC2, CABLES1, CACNB4, CDK8, FAF1, FOXO1, INPP4B, JMY +17 more | View in SCUBA |
About the gene
| Synonyms | APK1, COVA1, tNOX |
|---|---|
| Chromosome | X: 130622325-130903234 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Biological rhythms, Electron transport, Growth regulation, Transport |
Function
May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.