FAF1 — Fas associated factor 1
FAF1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FAF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Transcriptional Kinase Regulation Housekeeping | BNC2, CABLES1, CACNB4, CDK8, ENOX2, FOXO1, INPP4B, JMY +17 more | View in SCUBA |
| Neutrophils | Myeloid Maturation Developmental | AFF2, CERS6, DGKG, LRMDA, MSRB3, PKP4, RSRC1 |
About the gene
| Synonyms | CGI-03, hFAF1, HFAF1s, UBXD12, UBXN3A |
|---|---|
| Chromosome | 1: 50437028-50960267 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Apoptosis |
Function
Ubiquitin-binding protein. Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation. Potentiates but cannot initiate FAS-induced apoptosis (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.