CAPN6 — Calpain 6
CAPN6 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CAPN6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Wnt-niche Fibroblast Developmental | ALDH1A1, APCDD1L, CCDC80, EBF1, FGL2, IGF1, MEOX2, MGP +5 more | View in SCUBA |
About the gene
| Synonyms | CalpM, CANPX, CAPNX |
|---|---|
| Chromosome | X: 111245099-111270483 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Predicted intracellular proteins |
Function
Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.