Wnt-niche Fibroblast
Gene co-expression module in Fibroblasts
| Category | Developmental |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 14 genes have a known function matching the annotation |
Why this annotation
OGN (osteoglycin/mimecan) and MGP are ECM proteoglycans marking quiescent stromal fibroblasts. RSPO3 is a Wnt potentiator expressed by intestinal stromal niche cells. IGF1 supports epithelial growth. ALDH1A1 mediates retinoic acid synthesis, a key stromal niche signal. EBF1 and MEOX2 are TFs associated with mesenchymal identity. CCDC80 and APCDD1L are stromal markers. Module is strongly suppressed in inflammation and restored in remission, consistent with a homeostatic Wnt-niche fibroblast state.
Genes
ALDH1A1, APCDD1L, CAPN6, CCDC80, EBF1, FGL2, IGF1, MEOX2, MGP, OGN, PALMD, PPL, RSPO3, TMEFF2
Most correlated modules
- BMP-antagonizing Fibroblast · correlation 0.86
- Submucosal Fibroblast · correlation 0.85
- Subepithelial Fibroblast Identity · correlation 0.81
- Neural-crest Fibroblast · correlation 0.77
- CD34+ Quiescent Fibroblast · correlation 0.75
- Quiescent Stromal Identity · correlation 0.75
- Elastin-Fibronectin ECM · correlation 0.70
- PI16+ Fibroblast Identity · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.