EBF1 — EBF transcription factor 1
EBF1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EBF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Wnt-niche Fibroblast Developmental | ALDH1A1, APCDD1L, CAPN6, CCDC80, FGL2, IGF1, MEOX2, MGP +5 more | View in SCUBA |
| Hematopoietic progenitor cells | Pro-B Progenitor Lymphcyte development | ARPP21, CD79A, CD79B, CYGB, DNTT, FRMD4A, IL2RA, IL7R +4 more | |
| Lymphatic endothelial | Inflammatory cAMP Response Inflammation | ARL15, DIAPH2, HIP1, PDE4D, PDE7B, PELI2, PLCB4 | View in SCUBA |
| Smooth muscle cells | Mural/Pericyte Identity Development | C1QTNF1, FRMD4A, FRY, ITGA7, LGALSL, LGI4, MCAM, MEF2C +6 more | View in SCUBA |
About the gene
| Synonyms | COE1, EBF, OLF1 |
|---|---|
| Chromosome | 5: 158695916-159099916 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, Developmental protein, DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Key pioneer transcription factor of B-cell specification and commitment. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B- cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold (By similarity). (Microbial infection) Acts as a chromatin anchor for Epstein- Barr virus EBNA2 to mediate the assembly of EBNA2 chromatin complexes in B-cells. In addition, binds to the viral LMP1 proximal promoter and promotes its expression during latency.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.