MGP — Matrix Gla protein
MGP belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MGP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Wnt-niche Fibroblast Developmental | ALDH1A1, APCDD1L, CAPN6, CCDC80, EBF1, FGL2, IGF1, MEOX2 +5 more | View in SCUBA |
| Pericytes | Complement Regulatory Pericyte Inflammatory | ACTN1, CD63, CFH, IGFBP7, LGALS1, SELENOM, SERPING1 | View in SCUBA |
| Smooth muscle cells | Vascular Matrix Secretion ECM remodeling | ARPC1B, BGN, CALHM2, HSPB7, MXI1, RAB13, TRIM47 | View in SCUBA |
About the gene
| Chromosome | 12: 14880864-14885857 |
|---|---|
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Developmental protein |
| Biological process | Chondrogenesis, Differentiation, Osteogenesis |
Function
Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.