CD33 — CD33 molecule
CD33 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD33's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Macrophage Proliferation Cell cycle | ALDH16A1, ARL6IP4, BIN2, BRI3BP, CCDC112, CCP110, CD36, CD38 +15 more | View in SCUBA |
About the gene
| Synonyms | FLJ00391, p67, SIGLEC-3, SIGLEC3 |
|---|---|
| Chromosome | 19: 51225064-51243860 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, FDA approved drug targets, Plasma proteins, Predicted membrane proteins |
| Biological process | Cell adhesion |
Function
Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans. Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP- 2. In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules. One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.