Macrophage Proliferation
Gene co-expression module in Macrophages
| Category | Cell cycle |
|---|---|
| Genes | 24 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 24 genes have a known function matching the annotation |
Why this annotation
CCP110 is a centriole disengagement/centrosome marker; HLTF is a DNA damage-response E3 ubiquitin ligase active during replication; JADE1 promotes histone H4 acetylation and is linked to cell cycle progression; BRI3BP is upregulated in proliferating cells; UBTF and TCOF1 support ribosome biogenesis required for proliferation; SLC1A5 (ASCT2) is a glutamine transporter upregulated in proliferating cells; SLC25A39 supports mitochondrial one-carbon metabolism in proliferating cells. Multiple genes show 2–4x enrichment in prolif_mac subset, strongly supporting a proliferation program.
Genes
ALDH16A1, ARL6IP4, BIN2, BRI3BP, CCDC112, CCP110, CD33, CD36, CD38, DBNL, FZD2, HLTF, JADE1, MLEC, NAAA, NDUFA13, SCIMP, SECTM1, SLC1A5, SLC25A39, SLC2A8, TCOF1, TP53I13, UBTF
Most correlated modules
- Retromer Endosomal Sorting · correlation 0.91
- Efferocytosis Anti-inflammatory · correlation 0.91
- Lysosomal Hydrolase Program · correlation 0.90
- Innate Antiviral Sensing · correlation 0.87
- Translation Initiation · correlation 0.85
- DNA Replication Metabolism · correlation 0.84
- Macrophage Identity · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.