BIN2 — Bridging integrator 2
BIN2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BIN2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | TCR Proximal Signaling TCR Signaling | ADGRG5, C11orf21, C12orf75, CD300A, FGR, GPSM3, LAT, MATK +11 more | |
| Innate lymphoid cells | NK Cytotoxic Regulation Cytotoxicity | ARHGAP30, CAPN12, CHD9, CLK1, CTSC, CYB5B, DDX27, DNMT1 +29 more | View in SCUBA |
| Macrophages | Macrophage Proliferation Cell cycle | ALDH16A1, ARL6IP4, BRI3BP, CCDC112, CCP110, CD33, CD36, CD38 +15 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cytoskeletal Remodeling Migration migration & adhesion | ADAM8, C11orf21, CAPN1, CAPN2, CD52, CDC25B, CNN2, CYB561 +14 more | |
| Natural Killer cells | NK Degranulation Activation activation | CCND3, GPR141, OSBPL5, PXN, RASGRP2, SELPLG, SH3BP5, STING1 +3 more | View in SCUBA |
| Neutrophils | Degranulation Trafficking Degranulation | ATP11A, CSGALNACT2, FRY, KDM7A, LPGAT1, PYGL, RAB27A, RIN3 +7 more |
About the gene
| Synonyms | BRAP-1 |
|---|---|
| Chromosome | 12: 51281038-51324668 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
Function
Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.