CD38 — CD38 molecule
CD38 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD38's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Dark-zone GC B-cell B cell maturation | BRWD1, CCDC144A, CCDC88A, FGD6, LPP, MYBL1, MYO1E, RAPGEF5 +2 more | View in SCUBA |
| CD4⁺ T cells | T cell exhaustion Exhaustion | CD247, CD59, FLT1, GAN, IKBKB, LAG3, LRBA, PTMS +3 more | View in SCUBA |
| Gamma-delta T cells | Immature T Cell T cell maturation | A1BG, ACP5, CD7, ID3, ITM2C, MZB1, NCF1, NUDT14 +7 more | |
| Hematopoietic progenitor cells | Hematopoietic Progenitor Identity Stemness | DAD1, HSH2D, HYAL3, ITGAE, KIT, MBOAT2, MTHFD2, PARVB +2 more | |
| Macrophages | Macrophage Proliferation Cell cycle | ALDH16A1, ARL6IP4, BIN2, BRI3BP, CCDC112, CCP110, CD33, CD36 +15 more | View in SCUBA |
| Natural Killer cells | NK Cell Activation activation | ACTG1, ACTR2, ACTR3, LCP1, LNPEP, MSN, TLN1, XPO1 | View in SCUBA |
About the gene
| Synonyms | cADPR1 |
|---|---|
| Chromosome | 4: 15778275-15853232 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Receptor, Transferase |
Function
Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion. Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid. At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+). Has cADPR hydrolase activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.