SCUBA

ARL6IP4 — ADP ribosylation factor like GTPase 6 interacting protein 4

ARL6IP4 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ARL6IP4's module in each cell type

Cell typeModuleShares the module with
EndothelialInflammatory Stress Response
Inflammation		ADI1, APLN, ARL6IP1, CCDC88A, DAP, GPR68, HEBP2, ITGAV +11 moreView in SCUBA
Gamma-delta T cellsElectron Transport Chain
Mitochondrial & OxPhos		BBLN, C19orf53, COX5B, COX7A2, MIF, NDUFA4, NDUFB4, NME2 +6 more
Goblet cellsMitochondrial Biogenesis
Mitochondrial & OxPhos		ATP5F1D, CHCHD10, CISD3, CYBA, GADD45GIP1, METTL26, MIF, MRPL12 +3 moreView in SCUBA
Innate lymphoid cellsMitochondrial OxPhos
Mitochondrial & OxPhos		AKR7A2, ANXA6, AP2M1, ARPC1B, ATP5MC2, ATP5PB, BSG, CCNDBP1 +21 moreView in SCUBA
MacrophagesMacrophage Proliferation
Cell cycle		ALDH16A1, BIN2, BRI3BP, CCDC112, CCP110, CD33, CD36, CD38 +15 moreView in SCUBA
Mucosal-associated invariant T cellATP Synthase Complex
Mitochondrial & OxPhos		ATP5F1E, ATP5ME, ATP5MK, COMMD6, COPS9, COX7C, HAX1, NDUFA1 +3 more
Natural Killer cellsEnergy Metabolism
Metabolism		ATP5MC2, BLOC1S1, NDUFA11, NDUFB9, PGAM1, PKM, TRAPPC1View in SCUBA

About the gene

SynonymsSFRS20, SR-25, SRp25, SRrp37
Chromosome12: 122980060-122982913
Predicted locationIntracellular
Essential geneNo
Protein classPredicted intracellular proteins
Biological processmRNA processing, mRNA splicing

Function

Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site. In case of infection by Herpes simplex virus (HSVI), may act as a splicing inhibitor of HSVI pre-mRNA

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.