CES3 — Carboxylesterase 3
CES3 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CES3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Cellular Senescence Senescence & shedding | ABCA7, ARHGEF2, CASP3, CYP2B6, DGKD, DNAJC22, EXOC7, FBXL19 +24 more | View in SCUBA |
About the gene
| Synonyms | ES31, FLJ21736 |
|---|---|
| Chromosome | 16: 66961245-66975149 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Serine esterase |
Function
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]- carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.