Cellular Senescence
Gene co-expression module in Colonocytes
| Category | Senescence & shedding |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 33 genes have a known function matching the annotation |
Why this annotation
GLB1 (lysosomal beta-galactosidase, the canonical SA-β-gal senescence marker), CASP3 (executioner caspase, active in senescence-associated apoptosis and paracrine signaling), MICA (NKG2D stress ligand upregulated on senescent cells for immune clearance), and STAT2 (interferon-JAK-STAT, activated in senescence-associated secretory phenotype) anchor a senescence/stress program. TAOK2 (stress-activated MAP3K), ABCA7 (lipid efflux, lysosomal function), STAG1 (cohesin, DNA damage response), UBXN6 (ubiquitin regulatory X domain, proteostasis), and FBXL19 (F-box E3 ligase) are consistent with senescent colonocyte biology. The module is a topological neighbor of M34 which also shows sen_colono enrichment, reinforcing this interpretation.
Genes
Most correlated modules
- Ubiquitin-Proteasome System · correlation 0.83
- Senescent Colonocyte Transcription · correlation 0.83
- Inflammatory Cytoskeletal Remodeling · correlation 0.83
- Vesicular Trafficking · correlation 0.83
- Stem Cell Epigenetic · correlation 0.83
- Ribosome Biogenesis · correlation 0.76
- Actin-Motor Organization · correlation 0.74
- Fatty Acid Oxidation · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.