DGKD — Diacylglycerol kinase delta
DGKD belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DGKD's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | BCR signaling/maturation B cell maturation | ATP6V0A1, BCL11A, CAMK2D, CD22, CLEC2D, DDHD1, IL4R, ITPR1 +9 more | View in SCUBA |
| Endothelial | VEGF Tip Cell Signaling Endothelial cell development | ADAMTS5, BDKRB2, CA2, CBLB, CCND1, ESM1, GABRD, GNAI1 +7 more | View in SCUBA |
| Enterocytes | PPARA/FXR fatty acid oxidation Lipid metabolism | ALDH18A1, ANO10, CPT1A, FAT1, FMO5, NDRG1, NR1H4, PPARA +4 more | View in SCUBA |
| Gamma-delta T cells | RNA Binding/Splicing RNA processing & translation | AIMP1, ATP11B, C1orf43, CCT2, DEDD2, ENSA, ENY2, FBXL14 +18 more | |
| Neutrophils | Neutrophil Differentiation Developmental | DACH1, FAR1, MPP7, MSRA, PAM, PLCL2, PTBP2, RELL1 +1 more | |
| Smooth muscle cells | Lipid Kinase Signaling Housekeeping | ABTB1, ARRDC4, CACNA1H, CBX7, CX3CL1, DNTTIP2, FCHSD2, FYTTD1 +10 more | View in SCUBA |
About the gene
| Synonyms | DGKdelta, KIAA0145 |
|---|---|
| Chromosome | 2: 233354494-233472104 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Kinase, Transferase |
| Biological process | Endocytosis, Lipid metabolism, Protein transport, Transport |
Function
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (By similarity). May also regulate clathrin-dependent endocytosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.