CYP2B6 — Cytochrome P450 family 2 subfamily B member 6
CYP2B6 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CYP2B6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Cellular Senescence Senescence & shedding | ABCA7, ARHGEF2, CASP3, CES3, DGKD, DNAJC22, EXOC7, FBXL19 +24 more | View in SCUBA |
About the gene
| Synonyms | CPB6, CYP2B, CYPIIB6 |
|---|---|
| Chromosome | 19: 40991282-41018398 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Monooxygenase, Oxidoreductase |
| Biological process | Lipid metabolism |
Function
A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling. Hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2. Plays a role in the oxidative metabolism of xenobiotics, including plant lipids and drugs. Acts as a 1,4-cineole 2-exo- monooxygenase. Allele 2B6*9: Has low affinity for anandamide and can only produce 11,12 EpETrE-EAs
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.