CLCA1 — Chloride channel accessory 1
CLCA1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CLCA1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Inflammatory Goblet Remodeling Stress | C2CD4A, COL16A1, FMOD, GALNT8, GPX2, IFITM2, KCNE3, LYZ +3 more | View in SCUBA |
About the gene
| Synonyms | CaCC, CLCRG1 |
|---|---|
| Chromosome | 1: 86468368-86500259 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Predicted secreted proteins, Transporters |
| Molecular function | Hydrolase, Metalloprotease, Protease |
| Biological process | Calcium transport, Ion transport, Transport |
Function
May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.