Inflammatory Goblet Remodeling
Gene co-expression module in Goblet cells
| Category | Stress |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 12 genes have a known function matching the annotation |
Why this annotation
This module is strongly upregulated in both UC and CD inflammation (delta ~1.5 and 1.2) and reverses in remission. Hub genes include TGFBI (TGF-beta-induced, ECM/stress response), PROM1 (CD133, stem/progenitor marker), CLCA1 (goblet cell differentiation marker, chloride channel), PRUNE2 (tumor suppressor/stress), KCNE3 (ion channel, intestinal chloride secretion), C2CD4A (inflammatory gene regulated by cytokines), LYZ (lysozyme, antimicrobial), GALNT8 (mucin glycosylation), GPX2 (antioxidant), IFITM2 (interferon-induced transmembrane), FMOD (ECM proteoglycan), COL16A1 (collagen). The combination of CLCA1, LYZ, GALNT8 with TGFBI and inflammatory markers suggests this reflects an inflammation-associated goblet cell stress/remodeling state with partial loss of normal goblet identity (CLCA1 marker) mixed with ECM remodeling and antimicrobial response. Given the strong inflammation signal and the mix of goblet differentiation (CLCA1), antimicrobial (LYZ), and tissue remodeling (TGFBI, FMOD, COL16A1) genes, this is best labeled as inflammation-driven goblet stress/remodeling.
Genes
C2CD4A, CLCA1, COL16A1, FMOD, GALNT8, GPX2, IFITM2, KCNE3, LYZ, PROM1, PRUNE2, TGFBI
Most correlated modules
- Secreted Antimicrobials · correlation 0.83
- MHC Class I Antigen Presentation · correlation 0.79
- Mucin Glycosylation Remodeling · correlation 0.76
- MHC Class II Antigen Presentation · correlation 0.76
- Goblet Secretory Identity · correlation 0.71
- Pyroptosis Stress Response · correlation 0.58
- Hypoxia Metabolic Stress · correlation 0.57
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.