CLPX — Caseinolytic mitochondrial matrix peptidase chaperone subunit X
CLPX belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CLPX's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Ribosome Biogenesis Housekeeping | ABCE1, BCCIP, COX20, DDX18, DUS1L, EIF3B, IDH3A, IMP3 +17 more | View in SCUBA |
About the gene
| Chromosome | 15: 65148219-65185342 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Chaperone, Hydrolase |
Function
ATP-dependent chaperone that functions as an unfoldase. As part of the ClpXP protease complex, it recognizes specific protein substrates, unfolds them using energy derived from ATP hydrolysis, and then translocates them to the proteolytic subunit (CLPP) of the ClpXP complex for degradation. Thanks to its chaperone activity, it also functions in the incorporation of the pyridoxal phosphate cofactor into 5- aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis. This chaperone is also involved in the control of mtDNA nucleoid distribution, by regulating mitochondrial transcription factor A (TFAM) activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.