ABCE1 — ATP binding cassette subfamily E member 1
ABCE1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ABCE1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Actin Cytoskeletal Remodeling Cytoskeletal | ANXA2, CAMKK2, CORO1C, DBN1, EIF3J, MIF, PPP1R14B, PTP4A2 +3 more | View in SCUBA |
| Macrophages | Ribosome Biogenesis Housekeeping | BCCIP, CLPX, COX20, DDX18, DUS1L, EIF3B, IDH3A, IMP3 +17 more | View in SCUBA |
About the gene
| Synonyms | OABP, RLI, RLI1, RNASEL1, RNASELI, RNS4I |
|---|---|
| Chromosome | 4: 145098288-145129524 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins, Transporters |
| Molecular function | Chaperone, Hydrolase |
| Biological process | Host-virus interaction, Translation regulation |
Function
Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly. Able to hydrolyze ATP, GTP, UTP and CTP. Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits. Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway. Also plays a role in quality control of translation of mitochondrial outer membrane- localized mRNA. As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy. RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL. Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway. (Microbial infection) May act as a chaperone for post- translational events during HIV-1 capsid assembly. (Microbial infection) Plays a role in the down-regulation of the 2-5A/RNASEL pathway during encephalomyocarditis virus (EMCV) and HIV-1 infections
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.