DDX18 — DEAD-box helicase 18
DDX18 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DDX18's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | DNA Damage Repair DNA/chromatin regulation | ANKRD10, ASF1A, DNAJC17, ENPP5, KLRC4, KLRD1, NARS1, NDUFV3 +15 more | |
| Innate lymphoid cells | NK Cytokine Signaling Immune regulation | BORCS7, C6orf62, IER3, LMO4, MAT2A, NSUN6, PGGHG, PLCG2 +3 more | View in SCUBA |
| Macrophages | Ribosome Biogenesis Housekeeping | ABCE1, BCCIP, CLPX, COX20, DUS1L, EIF3B, IDH3A, IMP3 +17 more | View in SCUBA |
| Natural Killer cells | NRF2 Stress Response Stress | C1orf56, CNOT6L, CWC25, FAM133B, JOSD1, KMT2E, NFE2L2, PRMT9 +2 more | View in SCUBA |
About the gene
| Synonyms | Has1, MrDb |
|---|---|
| Chromosome | 2: 117814691-117832377 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Helicase, Hydrolase, RNA-binding |
Function
ATP-dependent RNA helicase that plays a role in the regulation of R-loop homeostasis in both endogenous R-loop-prone regions and at sites of DNA damage. At endogenous loci such as actively transcribed genes, may act as a helicase to resolve the formation of R- loop during transcription and prevent the interference of R-loop with DNA-replication machinery. Also participates in the removal of DNA- lesion-associated R-loop. Plays an essential role for establishing pluripotency during embryogenesis and for pluripotency maintenance in embryonic stem cells. Mechanistically, prevents the polycomb repressive complex 2 (PRC2) from accessing rDNA loci and protects the active chromatin status in nucleolus (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.