IMP3 — IMP U3 small nucleolar ribonucleoprotein 3
IMP3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IMP3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | RNA Processing Mixed RNA processing & translation | AUP1, B3GAT3, CFDP1, CMTM3, DENR, EIF4H, FBXW5, FUCA1 +13 more | View in SCUBA |
| Macrophages | Ribosome Biogenesis Housekeeping | ABCE1, BCCIP, CLPX, COX20, DDX18, DUS1L, EIF3B, IDH3A +17 more | View in SCUBA |
| Mucosal-associated invariant T cell | Immunoproteasome Activity Inflammation | ABRACL, ARPC5, BANF1, CARD16, CISD3, CYBC1, GIMAP2, PLAAT4 +4 more |
About the gene
| Synonyms | BRMS2, C15orf12, FLJ10968, MRPS4 |
|---|---|
| Chromosome | 15: 75639085-75648706 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins, Ribosomal proteins |
| Molecular function | Ribonucleoprotein, RNA-binding, rRNA-binding |
| Biological process | Ribosome biogenesis, rRNA processing |
Function
Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.