Ribosome Biogenesis
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 26 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 26 genes have a known function matching the annotation |
Why this annotation
The gene list is strongly enriched for ribosome biogenesis factors: RPF2, LTV1, RSL1D1, SDAD1, IMP3, RRP15, DDX18 are all pre-ribosomal assembly/maturation factors involved in 60S or 40S subunit processing. LARS1 is leucyl-tRNA synthetase. MTIF3 is mitochondrial translation initiation factor 3. COX20 is a Complex IV assembly chaperone. NDUFV3 is a Complex I subunit. IDH3A is isocitrate dehydrogenase (TCA cycle). CLPX is a mitochondrial AAA protease. TUBA1C is alpha-tubulin. The dominant program is ribosome biogenesis, with a secondary mitochondrial component. Prolif_mac enrichment for TUBA1C and COX20 is consistent with proliferating macrophages having elevated ribosome production and mitochondrial activity. Neighbor context (M63, M147 = RNA/protein synthesis) supports this as part of a ribosome biogenesis neighborhood.
Genes
ABCE1, BCCIP, CLPX, COX20, DDX18, DUS1L, EIF3B, IDH3A, IMP3, LARS1, LTV1, MRPS18B, MRPS35, MTIF3, NDUFV3, PDHA1, RPF2, RRP15, RSL1D1, SDAD1, SEH1L, TBC1D9B, TMEM192, TTC1, TUBA1C, TYW3
Most correlated modules
- RNA Processing & Repair · correlation 0.96
- Ribosome Biogenesis · correlation 0.93
- ER Protein Glycosylation · correlation 0.92
- Ubiquitin-Proteasome System · correlation 0.92
- Glycogen Metabolism · correlation 0.92
- Protein Biogenesis · correlation 0.92
- ER Morphology Stress · correlation 0.91
- ER Stress UPR · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.