COA1 — Cytochrome c oxidase assembly factor 1
COA1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
COA1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TGF-beta response Intercellular communication | CLU, ELK4, GLUL, GPR18, HDGFL3, ORAI2, RAB27B, RASSF2 +3 more | View in SCUBA |
| Innate lymphoid cells | cAMP-Glucocorticoid Suppression Immune regulation | CD7, CERK, CNDP2, NAP1L4, NEK7, NR3C1, PDE3B, PDE4D +3 more | View in SCUBA |
About the gene
| Synonyms | C7orf44, FLJ10803, MITRAC15 |
|---|---|
| Chromosome | 7: 43608456-43729717 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
Function
Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for assembly of mitochondrial respiratory chain complex I and complex IV. As part of the MCIA complex, required for efficient assembly of the mitochondrial complex I
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.