CD7 — CD7 molecule
CD7 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T-cell activation TCR/AP1/NFKb pathway | C16orf87, CAMK1, CBLB, CD4, CDK6, CIAO1, COPB2, DGUOK +7 more | View in SCUBA |
| CD8⁺ T cells | Gut Tissue Residency Gut residence | ALOX5AP, C4orf3, CAPN2, CD164, CD3D, CD99, CLIC3, ID2 +9 more | View in SCUBA |
| Gamma-delta T cells | Immature T Cell T cell maturation | A1BG, ACP5, CD38, ID3, ITM2C, MZB1, NCF1, NUDT14 +7 more | |
| Hematopoietic progenitor cells | ILC3/γδT Priming Lymphcyte development | C2CD4D, CCL1, CCR1, CD2, CHI3L2, FGR, GPR18, IL17RE +8 more | |
| Innate lymphoid cells | cAMP-Glucocorticoid Suppression Immune regulation | CERK, CNDP2, COA1, NAP1L4, NEK7, NR3C1, PDE3B, PDE4D +3 more | View in SCUBA |
| Natural Killer cells | NK Checkpoint Receptors Immune regulation | CD96, CRACR2B, DAPK2, ECH1, ECI2, ISYNA1, KIR2DL4, MAP4 +5 more | View in SCUBA |
About the gene
| Synonyms | GP40, LEU-9, Tp40, TP41 |
|---|---|
| Chromosome | 17: 82314868-82317608 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Adaptive immunity, Immunity |
Function
Transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors. Plays a costimulatory role in T-cell activation upon binding to its ligand K12/SECTM1. In turn, mediates the production of cytokines such as IL-2. On resting NK-cells, CD7 activation results in a significant induction of interferon-gamma levels.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.