SCUBA

Innate lymphoid cells: gene co-expression modules

Tissue-resident lymphocytes without antigen receptors, mirroring helper T subsets; responding to epithelial alarmins, they secrete cytokines that sustain barrier integrity, antimicrobial defence, and lymphoid tissue organisation.

SCUBA's reference network for Innate lymphoid cells holds 101 gene modules covering 2,159 genes. Each module is a group of genes that rise and fall together across these cells, annotated with the biological process it most likely represents.

View the Innate lymphoid cells network in SCUBA

activation (5)

Cell cycle (2)

Cell Cycle Entry · 7 genes
Cell Cycle Regulation · 7 genes

Cytoskeleton & motility (9)

Actin Cytoskeletal Regulation · 16 genes
Actin Cytoskeleton Dynamics · 35 genes
Actin Cytoskeleton Dynamics · 20 genes
Actin Cytoskeleton Remodeling · 26 genes
Centrosome & Scaffolding · 23 genes
Cytoskeletal Remodeling · 17 genes
ILC1 Actin Motility · 23 genes
ILC1 Cytoskeletal Metabolic · 23 genes
Septin Cytoskeleton · 27 genes

Cytotoxicity (4)

Differentiation (7)

ILC Identity Program · 38 genes
ILC Transcription Factor Program · 20 genes
ILC-1 identity · 29 genes
ILC3 identity · 40 genes
ILC3 identity · 28 genes
ILC3 Transcriptional Identity · 21 genes
NK/ILC1 Identity · 26 genes

DNA regulation & transcription (3)

AP-1 Transcriptional Activation · 37 genes
Transcriptional Activation · 18 genes
Transcriptional Regulation · 27 genes

Gut residency (1)

ILC Survival Residency · 34 genes

Homing & TEM (2)

NK Homing Circulating · 46 genes
NK ILC Tissue Homing · 34 genes

Immune regulation (6)

Antigen Processing MHC-I · 17 genes
cAMP-Glucocorticoid Suppression · 12 genes
Endosomal Trafficking Signaling · 25 genes
ILC1 Lymphocyte Signaling · 20 genes
Lymphocyte Apoptosis Regulation · 23 genes
NK Cytokine Signaling · 12 genes

Inflammation (13)

IFN-driven ILC1 Activation · 30 genes
IFN-gamma Response · 25 genes
ILC1 Inflammatory Activation · 30 genes
ILC1 Inflammatory Activation · 20 genes
Inflammasome Activation · 28 genes
Innate Immune Activation · 22 genes
Innate Inflammatory Activation · 16 genes
Innate Stress Signaling · 16 genes
Interferon-Stimulated Genes · 26 genes
JAK-STAT Cytokine Signaling · 32 genes
NF-κB Inflammatory Activation · 16 genes
NF-κB Inflammatory Activation · 35 genes
Prostaglandin-AP1 Response · 21 genes

Metabolism (6)

Cellular Metabolic Maintenance · 22 genes
Glycolysis & OxPhos · 19 genes
Glycolysis & OxPhos · 11 genes
Lipid & Isoprenoid Metabolism · 17 genes
Mixed Proteostasis Metabolism · 27 genes
Pyruvate Metabolism · 19 genes

Mitochondrial & OxPhos (10)

Mitochondrial Housekeeping · 17 genes
Mitochondrial Lysosomal Housekeeping · 16 genes
Mitochondrial Metabolic Housekeeping · 25 genes
Mitochondrial Metabolism · 21 genes
Mitochondrial Organization · 30 genes
Mitochondrial OxPhos · 30 genes
Mitochondrial OxPhos · 9 genes
Mitochondrial OxPhos Biogenesis · 31 genes
Mitochondrial Translation · 46 genes
Oxidative Phosphorylation · 24 genes

Protein processing & ER (8)

Endosomal Trafficking · 20 genes
ER-Golgi Trafficking · 24 genes
Proteasome & COPI Trafficking · 14 genes
Proteasome & TCA · 14 genes
Proteasome ER Proteostasis · 28 genes
Protein Biogenesis & Import · 15 genes
SUMOylation Program · 14 genes
TRiC Chaperonin Folding · 18 genes

RNA processing & translation (16)

Basal Housekeeping · 7 genes
Golgi RNA Processing · 20 genes
mRNA Stability & Splicing · 15 genes
mRNA Translation · 15 genes
Pre-mRNA Splicing · 12 genes
RNA Chromatin Regulation · 28 genes
RNA Chromatin Regulation · 14 genes
RNA Processing · 12 genes
RNA Processing & Proteostasis · 14 genes
RNA Processing & Proteostasis · 20 genes
RNA Processing Mixed · 22 genes
RNA Splicing Processing · 25 genes
RNA-binding & Splicing · 13 genes
Splicing & Transcription · 21 genes
Transcription RNA Processing · 20 genes
Translation Initiation · 15 genes

Stress (9)