NR3C1 — Nuclear receptor subfamily 3 group C member 1
NR3C1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NR3C1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Germinal center B-cell B cell maturation | BACH2, BCL6, BPTF, GGA2, MAP4K4, MBD4, MCTP2, MSI2 +7 more | View in SCUBA |
| CD4⁺ T cells | NFAT activation TCR/AP1/NFKb pathway | AHI1, ASAP1, BCAT1, BICDL1, CPM, CYP7B1, ETV6, FAM107B +13 more | View in SCUBA |
| Fibroblasts | TGF-beta Response ECM remodeling | C1orf21, CBR3, CNRIP1, DOK5, FREM1, GUSB, HTRA1, LRRN4CL +7 more | View in SCUBA |
| Gamma-delta T cells | Chromatin Remodeling Signaling DNA/chromatin regulation | AKAP13, BPTF, CARNMT1, CCDC6, CFLAR, CLASP1, CLASP2, DOCK10 +23 more | |
| Innate lymphoid cells | cAMP-Glucocorticoid Suppression Immune regulation | CD7, CERK, CNDP2, COA1, NAP1L4, NEK7, PDE3B, PDE4D +3 more | View in SCUBA |
| Mucosal-associated invariant T cell | Transcriptional Repression Immune regulation | ANKRD11, CMIP, MXI1, PELI2, PROSER1, RB1CC1, RCOR1, RFTN1 +7 more | |
| Smooth muscle cells | Vasoconstrictor Signaling Contractility | ARHGAP29, ATP10A, BBX, CDK18, CSRP2, EDNRA, GPAT2, NUDT4 +4 more | View in SCUBA |
About the gene
| Synonyms | GR, GRL |
|---|---|
| Chromosome | 5: 143277931-143435512 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, Human disease related genes, Nuclear receptors, Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | Chromatin regulator, DNA-binding, Receptor, RNA-binding |
| Biological process | Apoptosis, Cell cycle, Cell division, Chromosome partition, Mitosis, Transcription, Transcription regulation |
Function
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). Has transcriptional activation and repression activity. Mediates glucocorticoid-induced apoptosis. Promotes accurate chromosome segregation during mitosis. May act as a tumor suppressor. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). Acts as a dominant negative inhibitor of isoform Alpha. Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed. Loses this transcription modulator function on its own. Has no hormone-binding activity. May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner. Directly regulates STAT1 expression in isoform Alpha-independent manner. Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism. Increases activity of isoform Alpha. More effective than isoform Alpha in transcriptional activation, but not repression activity. Has transcriptional activation activity. Has transcriptional activation activity. Has transcriptional activation activity. Has highest transcriptional activation activity of all isoforms created by alternative initiation. Has transcriptional repression activity. Mediates glucocorticoid-induced apoptosis. Has transcriptional activation activity. Has transcriptional activation activity. Has lowest transcriptional activation activity of all isoforms created by alternative initiation. Has transcriptional repression activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.