PDE4D — Phosphodiesterase 4D
PDE4D belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PDE4D's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Effector activation NFkB TCR/AP1/NFKb pathway | ADAM19, AHR, ARFGAP3, ATF5, BHLHE40, CGAS, DUSP5, ETF1 +23 more | View in SCUBA |
| Enterocytes | YAP cytoskeletal remodeling Migration & adhesion | ABLIM1, AHCYL2, ARHGAP26, CCSER1, CDC42BPA, FGD4, ITGB8, PIP5K1B +5 more | View in SCUBA |
| Innate lymphoid cells | cAMP-Glucocorticoid Suppression Immune regulation | CD7, CERK, CNDP2, COA1, NAP1L4, NEK7, NR3C1, PDE3B +3 more | View in SCUBA |
| Lymphatic endothelial | Inflammatory cAMP Response Inflammation | ARL15, DIAPH2, EBF1, HIP1, PDE7B, PELI2, PLCB4 | View in SCUBA |
| Mucosal-associated invariant T cell | Post-translational Regulation Housekeeping | CCDC93, CD55, FBXO33, GALC, KCTD20, KDM2B, MGAT4A, MSL2 +8 more | |
| Natural Killer cells | NK Cell Exhaustion Immune regulation | CEBPB, CEMIP2, DENND3, FMNL1, HAVCR2, IFNGR1, METRNL, PRNP +3 more | View in SCUBA |
| Neutrophils | Myeloid Lipid Remodeling Developmental | ADK, AGPS, ATP8A1, ATP8B4, CLTCL1, DOP1B, ERG, GPD2 +3 more |
About the gene
| Synonyms | DPDE3 |
|---|---|
| Chromosome | 5: 58969038-60522120 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.