CRTC3 — CREB regulated transcription coactivator 3
CRTC3 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CRTC3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | RAB-mediated Trafficking Vesicular traficking | ABI1, ACSL3, ARMC8, CACUL1, CD86, CHST15, CTNNA1, CUL4A +27 more | View in SCUBA |
About the gene
| Synonyms | FLJ21868 |
|---|---|
| Chromosome | 15: 90529923-90645345 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted intracellular proteins |
| Molecular function | Activator |
| Biological process | Host-virus interaction, Transcription, Transcription regulation |
Function
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.