CTNNA1 — Catenin alpha 1
CTNNA1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CTNNA1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Th1 IL12 response Immune regulation | ADCY3, AKIRIN2, ETV7, HIVEP3, IL12RB2, JAKMIP1, PTPN1, RFTN1 +2 more | View in SCUBA |
| Endothelial | Integrin-Actin Adhesion migration & adhesion | APP, CHD3, DAG1, DOCK6, FKBP9, FMNL3, ITGA9, ITGB1 +6 more | View in SCUBA |
| Gamma-delta T cells | Lysosomal Biogenesis Protein processing & ER | ABI3, APLP2, ATP10A, B3GALT4, BAX, CD63, DOCK5, EML2 +14 more | |
| Goblet cells | Epithelial Junction Integrity migration & adhesion | ACTR2, ANXA2, DSC2, GLUL, PERP, SERPINB1, TNFSF10 | View in SCUBA |
| Macrophages | RAB-mediated Trafficking Vesicular traficking | ABI1, ACSL3, ARMC8, CACUL1, CD86, CHST15, CRTC3, CUL4A +27 more | View in SCUBA |
| Pericytes | Golgi Vesicular Trafficking Vesicular traficking | APP, CLIC4, EMP2, GNAS, PAK2, PTTG1IP, SERINC3, TGOLN2 +1 more | View in SCUBA |
| Smooth muscle cells | Sparse Mitoribosomal Housekeeping Housekeeping | CEP63, CIB1, ERGIC3, FBXO17, LEPROT, MRPL32, MRPL41, MRPS7 +6 more | View in SCUBA |
About the gene
| Synonyms | CAP102 |
|---|---|
| Chromosome | 5: 138610967-138935034 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Cell adhesion |
Function
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1- dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.