ACSL3 — Acyl-CoA synthetase long chain family member 3
ACSL3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ACSL3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | RAB-mediated Trafficking Vesicular traficking | ABI1, ARMC8, CACUL1, CD86, CHST15, CRTC3, CTNNA1, CUL4A +27 more | View in SCUBA |
| Smooth muscle cells | KLF6/ZNF24 regulators Activation | ARHGAP1, CTBP2, KLF6, PLEKHA4, SCAF11, TNFAIP8L3, ZNF24 | View in SCUBA |
About the gene
| Synonyms | ACS3, FACL3, PRO2194 |
|---|---|
| Chromosome | 2: 222860942-222944639 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Ligase |
| Biological process | Fatty acid metabolism, Lipid metabolism |
Function
Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta- oxidation. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.