RAB-mediated Trafficking
Gene co-expression module in Macrophages
| Category | Vesicular traficking |
|---|---|
| Genes | 36 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 36 genes have a known function matching the annotation |
Why this annotation
Multiple RAB GTPases (RAB31, RAB10, RAB1A, RAB6A) are prominent, covering early endosomes, recycling endosomes, ER-to-Golgi, and Golgi trafficking respectively. ABI1 (WAVE complex, actin polymerization at endosomes), CTNNA1 (actin-adhesion), STAU1 (RNA transport granules), LYN (myeloid Src kinase), PIK3CB (PI3K, endosomal signaling), MAP3K7/TAK1 (innate signaling), ACSL3 (lipid droplet/membrane fatty acid activation), OSBPL8 (oxysterol binding, lipid transfer at ER-endosome contacts). The RAB GTPase cluster is the dominant theme, pointing to broad vesicular trafficking across multiple compartments in macrophages.
Genes
ABI1, ACSL3, ARMC8, CACUL1, CD86, CHST15, CRTC3, CTNNA1, CUL4A, GNB1, KPNA6, LYN, MAP3K7, MICU2, MOB1B, N4BP1, NFYC, OSBPL8, PCGF5, PIK3CB, PPP4R1, PRPF18, RAB10, RAB11A, RAB1A, RAB31, RAB6A, RAB7A, RUFY1, STAU1, TAB2, TAB3, TMEM181, TMOD3, TNPO3, WDR26
Most correlated modules
- RNA Processing Transport · correlation 0.97
- Endolysosomal Trafficking · correlation 0.96
- ER-Golgi Trafficking · correlation 0.96
- Endolysosomal Trafficking · correlation 0.96
- Sphingolipid Membrane Homeostasis · correlation 0.96
- Microtubule Organization · correlation 0.96
- NF-κB AP-1 Signaling · correlation 0.95
- ER-Golgi Trafficking · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.