DCP1A — Decapping mRNA 1A
DCP1A belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DCP1A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Transcriptional Regulation Housekeeping | AATF, ABHD5, ARID3B, GGNBP2, MIA2, MSI2, NR2C2, NSMAF +18 more | View in SCUBA |
About the gene
| Synonyms | HSA275986, SMAD4IP1, SMIF |
|---|---|
| Chromosome | 3: 53283429-53347586 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Plasma proteins, Predicted intracellular proteins, Transporters |
| Molecular function | Hydrolase |
| Biological process | Nonsense-mediated mRNA decay |
Function
Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. Essential for embryonic development.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.