Transcriptional Regulation
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 27 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 27 genes have a known function matching the annotation |
Why this annotation
Hub genes include PPP4R3B (PP4 phosphatase complex, DNA damage/transcription regulation), RNF115/BCA2 (E3 ubiquitin ligase, endosomal trafficking and transcription), SYNRG (AP1 clathrin adaptor synergin), DCP1A (mRNA decapping, P-body), NR2C2/TR4 (nuclear receptor transcription factor), ARID3B (AT-rich interaction domain chromatin remodeling), TAF15 (RNA Pol II general transcription factor), AATF (anti-apoptotic transcription co-factor), ZNF518A/ZNF264 (zinc finger transcription factors), SS18 (SWI/SNF chromatin remodeling). Transcriptional regulators and chromatin remodeling factors dominate, with DCP1A linking to mRNA processing. The module reflects a broad transcriptional regulatory program in mono_mac.
Genes
AATF, ABHD5, ARID3B, DCP1A, GGNBP2, MIA2, MSI2, NR2C2, NSMAF, PCNX4, PHACTR1, PLAA, POM121C, PPP4R3B, RASGRP3, RNF115, SLC35E3, SPG7, SS18, SYNRG, TAF15, TIMM23, TMCC3, TMEM65, ZNF264, ZNF431, ZNF518A
Most correlated modules
- Microtubule Organization · correlation 0.94
- NF-κB AP-1 Signaling · correlation 0.94
- Endolysosomal Trafficking · correlation 0.93
- Transcriptional Regulation · correlation 0.93
- Monocyte Lipid Metabolism · correlation 0.92
- RAB-mediated Trafficking · correlation 0.92
- Transcriptional Repression · correlation 0.91
- Hypoxia-driven Activation · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.